Reviewed By
Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.8
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Read More
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Read More
Most Useful Reviews
9
Maintains heart health
I take B12 for heart health, and I always choose Now Foods.
Read More
7.5
Boosts heart safety
This supplement is excellent, dissolving quickly and tasting like candy. Sublingual absorption maximises benefits, while calcium aids its uptake. Vitamin B12 lowers homocysteine levels, lessening the risk of heart attacks and helping with liver health and mental well-being.
Read More
7.5
Eases heart irregularities
Taking B12 has alleviated heart palpitations and discomfort associated with irregular heartbeats.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
- All Researches
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Read More
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Maintains heart health
I take B12 for heart health, and I always choose Now Foods.
Read More
7.5
Boosts heart safety
This supplement is excellent, dissolving quickly and tasting like candy. Sublingual absorption maximises benefits, while calcium aids its uptake. Vitamin B12 lowers homocysteine levels, lessening the risk of heart attacks and helping with liver health and mental well-being.
Read More
7.5
Eases heart irregularities
Taking B12 has alleviated heart palpitations and discomfort associated with irregular heartbeats.
Read More
7.5
Supports heart health
25 people found this helpful
Excellent vitamins. I really respect Now Foods, so I chose their B-12. It’s affordable, with a large canister. The pink, cherry-flavoured lozenges are delightful. Vitamin B12 lowers homocysteine levels, reducing the risk of heart attacks. It also aids in producing choline, which helps combat poor dietary habits and liver issues, while participating in amino acid synthesis that boosts mental activity and positive emotions.
Read More
7.5
Improves heart function
19 people found this helpful
I bought vitamin B12 for its crucial role in the body, especially in improving the nervous system and enhancing the absorption of macronutrients. It positively impacts heart muscle function and helps maintain blood pressure. I will update my review post-course.
Read More
Frequently Asked Questions
7.5
Eases heart irregularities
Taking B12 has alleviated heart palpitations and discomfort associated with irregular heartbeats.
7.5
Essential for heart health
6 people found this helpful
The product arrived quickly. I ordered several vitamins, including B12. The small pink lozenges are easy to use and taste good. Vitamin B12 is vital for metabolic processes, as it lowers homocysteine, which protects against heart attacks and is essential for blood cell formation and nervous system health.
7.5
Improves heart function
19 people found this helpful
I bought vitamin B12 for its crucial role in the body, especially in improving the nervous system and enhancing the absorption of macronutrients. It positively impacts heart muscle function and helps maintain blood pressure. I will update my review post-course.
7.5
Boosts heart safety
This supplement is excellent, dissolving quickly and tasting like candy. Sublingual absorption maximises benefits, while calcium aids its uptake. Vitamin B12 lowers homocysteine levels, lessening the risk of heart attacks and helping with liver health and mental well-being.
7.5
Supports heart health
25 people found this helpful
Excellent vitamins. I really respect Now Foods, so I chose their B-12. It’s affordable, with a large canister. The pink, cherry-flavoured lozenges are delightful. Vitamin B12 lowers homocysteine levels, reducing the risk of heart attacks. It also aids in producing choline, which helps combat poor dietary habits and liver issues, while participating in amino acid synthesis that boosts mental activity and positive emotions.
1
Reduces heart palpitations
2 people found this helpful
I had high homocysteine levels and noticed significant cognitive clarity after taking vitamins B6 and B12. However, my homocysteine increased alarming after switching brands. I felt a notable mental fog while taking B12. Listen to your body; disappointment ensued.
7.5
Fights heart disease
5 people found this helpful
Vitamin B12 deficiency is common now, especially among vegetarians and seniors. It’s crucial for DNA production and nervous system function while lowering heart disease risk. Symptoms include fatigue and memory issues. The pale pink sucking tablets are effective, tasty, and have seemed to provide significant benefits.
2
We explored the role of vitamin B12 in relation to heart attacks by examining the effects of a combination therapy including B-vitamins and folate in patients with coronary artery disease (CAD). In a large-scale study involving nearly 2,000 participants, the researchers monitored how these vitamins impacted fibrin clot characteristics and the risk of heart attack over several years.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
Surprisingly, our findings indicated that vitamin B12 alone, as part of the combination therapy, did not significantly influence heart attack risk or outcomes. Instead, other factors like homocysteine thiolactone and plasma cysteine emerged as key players in determining clot properties and predicting adverse outcomes.
While we noted that baseline clot lysis time and maximum absorbance were associated with higher risks of acute myocardial infarction and mortality, the treatment with B-vitamins did not alter these markers significantly. Thus, the lack of efficacy from vitamin B12 in this context raises important questions about its effectiveness in preventing heart attacks when administered with other nutrients.
4
Vitamin B12 shows no heart attack benefit
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
References
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
- Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. 10.1111/joim.12834
